Jaundice of 16mg/dl after 40 hours of birth is an anomaly, and jaundice visible to the naked eye can occur in newborns with serum bilirubin exceeding 5-7mg/dl. It may be related to pathologic factors, such as hepatic bilirubin metabolism disorder, bile excretion disorder. The jaundice value of a newborn baby reaches 16mg/dl at 40 hours of birth, which belongs to a relatively high range. Most of the newborn babies are considered to be related to pathologic jaundice, which may be related to pathological factors, such as bile excretion disorders, hepatic bilirubin metabolism disorders, and excessive bilirubin production, etc. It is necessary to go to the hospital for further examination, and it is necessary to cooperate with the blue light irradiation in addition to controlling the primary pathology. If the jaundice value rises rapidly, the value is high, or the jaundice value still does not decrease after treatment, it may be necessary to consider the blood exchange treatment. Normally, letting the newborn baby have more sunshine and more stools will help to improve the jaundice. Parents need to follow the doctor’s instructions and treat the child aggressively to avoid neurological sequelae.