Among skin tumors, there is a kind of tumor called “extramammary Paget’s disease”, the early symptoms are similar to eczema dermatitis, so it is also called “extramammary eczema-like carcinoma”. This disease often occurs in the perineum where the sweat glands are rich, such as scrotum, penis, mons pubis, perineum and labia majora and minora, and in a few people it can occur in the armpit. The onset of the disease is common in men over 50 years of age, but it can also occur in women. The lesions start as single, well-defined red lesions with oozing, crusting or flaking on the surface, and gradually expand and infiltrate the surrounding area, or even develop ulcers on the surface and become pruritic. The etiology of the disease is unclear, and is generally divided into primary and secondary, with secondary often arising from the extension of rectal, cervical or bladder cancers. The disease is often mistaken for “dermatitis eczema” at the beginning, thinking that there is no big deal, because it is mostly located in the “private” parts, patients are generally shy about going to the hospital, and buy some topical medicine on their own, so that the symptoms can be relieved, which not only covers up the disease, but also delays the treatment. This not only conceals the disease, but also delays the treatment, and even leads to the evil consequences of tumor metastasis. Therefore, this disease has become the invisible “killer” of middle-aged and elderly people. As long as it is treated correctly and in time, it does not need chemotherapy, it can be completely cured. If the disease is not suitable for surgery, i.e. there are contraindications to surgery, radiotherapy and photodynamic therapy can be considered. The key to surgical treatment is whether the tumor cells can be cleared, thus reducing the recurrence rate of the tumor. Mohs’ microsurgery technique has been a common treatment method used by dermatologic surgeons abroad for the treatment of skin malignant tumors. This method not only allows for precise excision of tumor lesions, but also allows for the removal of tumor cells with minimal surgical incisions, thereby reducing tumor recurrence. In addition, the follow-up of the disease is also very important, and the time of the follow-up is also based on the depth of tumor infiltration. The thicker the tumor is, the shorter the follow-up interval can be, for example, once in 2 months, and once in half a year if there is no recurrence after 1 year. To remind middle-aged and elderly friends, if eczema-like skin damage such as erythema, erosion and itching appear in private parts such as vulva and perianal area for a long time, and the symptoms are prolonged, please do not be careless and embarrassed, but need to go to the hospital in time, and perform skin histopathological biopsy if necessary to exclude the possibility of extramammary Paget’s disease. Through timely and appropriate treatment, it can be completely treated and also make your life happier and healthier in old age.