In clinical practice, cranial defect is a very common disorder, and many patients suffer from serious cranial defects after craniotomy due to traffic accidents, falling objects or some craniosynostosis. It is certain that the image of skull defect is destroyed, and more importantly, skull defect will induce a series of neurological problems, which is very harmful, so skull repair surgery is usually needed as soon as possible. When it comes to skull repair surgery, there are two points that patients need to pay attention to, one is to choose a good hospital and experienced experts to do it, and the other is to choose the really ideal skull repair material. At present, the more widely used material is titanium mesh material, like many local general hospitals generally use titanium mesh material for surgery. Although titanium mesh material is progressive, it also has a lot of defects, and there may be infection, rejection, scalp abrasion and material exposure after surgery. Titanium mesh material has more problems and defects, and for better skull repair results, the new polyetheretherketone peek material is recommended. This is a very safe polymer material, its various properties are excellent, comparable to human skull, making up for the various disadvantages of titanium mesh material, and becoming the ideal material for skull repair surgery. The peek material is a valuable medical material that is included in the scope of reimbursement and can be reimbursed at a certain rate. It is recommended that patients should undergo skull repair surgery as soon as possible for early recovery.