The common clinical antipyretic suppositories include acetaminophen suppositories and compounded pediatric antipyretic suppositories. Children’s fever often use antipyretic suppositories will have certain effects, parents should pay attention. 1. Acetaminophen suppositories: Acetaminophen suppositories are suitable for children’s fever caused by common cold or influenza, and can also relieve mild to moderate pain. Acetaminophen suppositories are administered through the rectum, and adverse reactions such as rash and hives are occasionally seen after administration. If this drug is frequently used for fever in children, the main effect is to cause liver and kidney function abnormalities. Therefore, acetaminophen suppositories are forbidden for people with severe liver and kidney insufficiency, while people who are allergic to aspirin, people with liver and kidney insufficiency, and people with allergies should be cautious of using this drug. 2. Compound Pediatric Antipyretic Suppositories: Compound Pediatric Antipyretic Suppositories is a kind of Chinese patent medicine, which has the functions of antipyretic, analgesic, detoxification, and so on, and it is suitable for children’s fever, sore throat and other diseases. The main effect of children’s fever often use this drug is to cause liver and kidney function abnormalities, so the drug should not be used for more than 3 days, parents should pay attention. Some children may have adverse reactions such as rash, urticaria, granulocytopenia after using the drug, and it is contraindicated for people with severe liver and kidney insufficiency and those who are allergic to the product. In order to minimize the impact of the drug on children, fever should be actively taken to physical cooling, such as ice packs on the head, warm water baths and so on. If the fever is serious, if necessary, follow the doctor’s instructions to use medication, parents should not use the drug on their own.