The symptoms of this disease are mainly itchy skin, mainly itchy skin on the abdomen, palms and feet, and the itchy symptoms are heavy at night but mild during the day. When a patient has itchy skin, he should go to the hospital on an empty stomach for a blood bile acid test. Bile acid above 10 μmol/L can be diagnosed as intrahepatic cholestasis during pregnancy. The main effects of this disease on the fetus are intrauterine hypoxia and even intrauterine fetal death without warning, and on the pregnant woman by affecting the blood clotting function leading to postpartum hemorrhage and damage to liver function. Once diagnosed, intrahepatic cholestasis during pregnancy should be treated with bile acid-lowering therapy.