Some glucose-lowering medications can reduce weight, such as metformin, inhibitors of the SGLT-2 class, and GLP-1 receptor agonists, which can both lower glucose and reduce weight. There are also some hypoglycemic agents that can increase weight, such as sulfonylureas or glinides, thiazolidinediones, and insulin. There are also some hypoglycemic drugs that have a neutral effect on weight, such as glucosidase inhibitors or DPP4 enzyme inhibitors. Metformin reduces body weight mainly through appetite suppression, reduces caloric intake, improves hyperinsulinemia, reduces basal insulin and post-load insulin levels, and increases leptin sensitivity.GLP-1 agonists reduce body weight mainly through central and peripheral mechanisms, suppressing appetite, increasing energy expenditure, acting on the gastrointestinal tract, and delaying gastric emptying and gastrointestinal peristalsis.