Nipple discharge is a general term for a large group of conditions within breast disease. Nipple discharge has the following colors: 1, colored nipple discharge, including purulent yellow or yellow-green; 2, bloody bright red, dark red, curry, and even some old bleeding is black; 3, nipple discharge in the most common, colorless and transparent. The three types of nipple overflow for patients need to pay attention to, especially the latter two, bloody overflow and colorless and transparent overflow in the clinic means that there is a certain chance of breast malignant lesions, especially the risk of intraductal carcinoma will be relatively high, it is recommended that the patient to seek early diagnosis. In terms of examination, we can consider doing nuclear magnetic or breast ductoscopy to clarify the diagnosis, but the treatment is still recommended to be mainly surgical treatment.