There are five main possibilities for chest pain in adolescents: First, chest trauma, mostly with a clear history of trauma, manifested as chest swelling and pain and accompanied by skin spot formation. Secondly, costochondritis, which occurs in the 2-4 intercostal space, the clinical symptom is mainly stabbing pain in the chest, and the pain is aggravated by exertion or cold. Third, pleurisy, mostly secondary to lung infection, manifested as limited dull pain in the chest, and the pain is aggravated by deep breathing. Fourth, gynecomastia, a common disease of male breast. Clinical manifestation is enlargement of breasts, accompanied by breast swelling and discomfort. Fifth, lung cancer, manifested as stabbing pain in chest, which may be accompanied by cough or hemoptysis, there are various reasons causing chest pain in adolescents. When chest pain occurs, one should go to regular hospitals in time to clarify the cause of pain and actively cooperate with specialists for treatment, which will not cause serious clinical consequences.