Cerebral infarction paralysis is complicated by pneumonia and multiple sputum manifestations, which may be life-threatening if not treated in time. Cerebral infarction paralysis mostly exists in different degrees of swallowing and cough reflex disorder, if the patient develops intrapulmonary infection, which is not cured, it will lead to serious complications such as multi-drug-resistant pneumonia, sepsis, respiratory failure and so on, which will result in respiratory failure and jeopardize life. When the above symptoms occur, timely consultation should be made, sputum should be tested for drug sensitivity, and targeted drug treatment should be used, such as vancomycin, linezolid and other antibiotics for methicillin-resistant Staphylococcus aureus, and mechanical ventilation can be used for persistent hypoxemia. The above drugs need to be used under the guidance of clinicians, and unauthorized use of drugs is prohibited. It is recommended that patients go to the hospital in time to avoid delaying their condition.