An increase in blood pressure differential is an abnormal condition, especially when the differential pressure increases significantly, often due to pathological reasons, so a large blood pressure differential is not a good condition. The differential pressure mainly refers to the difference between systolic and diastolic blood pressure, the normal differential pressure is 30-40mmHg, differential pressure > 40mmHg is increased differential pressure, when the differential pressure ≥ 60mmHg is significantly increased differential pressure. A mild increase in differential pressure does not produce significant adverse consequences, but when the differential pressure increases significantly, it is often seen in pathological conditions such as severe anemia, hyperthyroidism, aortic valve insufficiency, and atherosclerosis. If there is a clinically significant increase in blood pressure differential, the cause of the significantly increased differential pressure needs to be actively sought so that treatment can be actively given.