Compression of the duodenum can not cure the ulcer, it is recommended to improve the lifestyle under the guidance of the doctor, the use of omeprazole and other medications, if necessary, surgical treatment. Duodenal ulcer is caused by excessive gastric juice secretion and intestinal mucosal barrier function weakening of the duodenal mucosal inflammatory defect, often manifested as chronic, regular epigastric pain, mostly in the fasting episodes, can be relieved after eating. Compression of the duodenum cannot cure duodenal ulcer. Duodenal ulcer should be timely to the hospital, through the improvement of lifestyle, medication and other ways to improve the condition, if necessary, need to endoscopic or surgical treatment. Lifestyle improvement mainly involves regular diet, abstaining from smoking and alcohol, drinking less coffee, strong tea and other stimulating beverages, reducing mental stress, and stopping unnecessary non-steroidal anti-inflammatory drugs, such as aspirin. Drug therapy includes proton pump inhibitors, such as omeprazole, pantoprazole, etc., H2 receptor inhibitors, such as famotidine, etc., which can inhibit the secretion of gastric acid; it can also be used to protect the gastric mucosa with weakly alkaline antacids, such as magnesium aluminum carbonate, aluminum thioglycollate and other drugs. When duodenal ulcer is combined with bleeding, perforation, obstruction and other complications, endoscopic and surgical treatment may be required. The above drugs should be used under the guidance of a medical professional. Patients with duodenal ulcer should seek immediate medical attention and early treatment under the guidance of a medical professional.