How are sperm produced, developed, matured and transported?

How sperm quality is directly related to fertility, and understanding how sperm are produced, developed, matured and transported is important in exploring male infertility. Spermatozoa are produced in the testes. The testis is composed of 200-300 testicular lobules, each of which in turn consists of 1-4 thin and long varicose seminal ducts. The spermatogenic epithelium of the varicose seminal ducts has two types of cells: testicular supporting cells and spermatogenic cells. Spermatogonia are in different stages of development, namely spermatogonia, primary spermatocytes, secondary spermatocytes and spermatocytes. A spermatogonial cell develops into 64 primary spermatocytes after six mitotic divisions, and a primary spermatocyte changes into two spermatocytes in one meiotic division. The spermatocyte undergoes 19 stages of processing and modification, and finally develops into a tadpole-shaped spermatozoon. The spermatozoa enter the lumen of the varicocele, which contracts to transport the spermatozoa into the epididymis, where they need 2-3 weeks of gestation to develop into spermatozoa with insemination capacity. Thus, it seems that sperm maturation requires a complex process and a certain amount of time. Knowing that it takes 70-90 days for spermatogonia to develop and mature into sperm, it is therefore possible to understand why the course of treatment for infertility caused by testicular factors should not be less than 3 months, so it is important to have confidence in the treatment and to adhere to the medication in order to be effective.