The diabetic foot is the most common and serious complication of diabetes, with an incidence of 10-20% of diabetic patients, and can directly lead to reduced quality of life, disability and even death. Diabetic foot has a high disability rate, requiring amputation in about 5-10% of cases and accounting for more than 50% of all non-traumatic amputations. The cost of chronic complications of diabetes accounts for 70-80% of the lifetime treatment cost of diabetes. Traditional conservative treatment of the diabetic foot is not very effective. Sympathetic denervation by lumbar sympathetic block or radiofrequency thermocoagulation effectively increases vascular and nerve tone and blocks sympathetic DD pain coupling. The result is vasodilation of the lower extremity with increased effective perfusion; establishment of collateral circulation with increased oxygen-carrying capacity; increased vascular perfusion of the lower extremity nerves and accompanying tissues, and nerve regeneration and remodeling. Lumbar sympathetic nerve block or radiofrequency thermal coagulation sympathetic nerve denervation can provide timely and effective treatment for cold extremities and intermittent claudication of prediabetic foot caused by macrovascular disease, recanalize occluded blood vessels, improve large vessel perfusion, improve blood supply to the distal extremities, and prevent or reduce the occurrence of diabetic foot. Carrying out minimally invasive treatment for prediabetic foot improves the quality of life of patients, avoids or reduces the occurrence of diabetic foot, and is undoubtedly a good burden-reducing process for society and family, with extremely obvious social benefits.