Spironolactone and furosemide can be used in combination, both belong to the antihypertensive and diuretic drugs, usually as a combination of drugs for the treatment of patients with high blood pressure, the use of drugs should be under the guidance of a doctor. Spironolactone is a steroidal compound, belonging to the low potency diuretic drugs, also known as potassium-preserving diuretics. The drug can act on the renal tubules, inhibit sodium-potassium exchange as well as the role of aldosterone, play the role of potassium-preserving diuretic, but its diuretic effect is weak. It is commonly used in clinical practice as an adjunct to edematous disorders and hypertension. Spironolactone may have adverse reactions such as hyperkalemia, nausea and vomiting, and this drug is contraindicated in patients with hyperkalemia. Furosemide is a highly effective diuretic, also known as tachyphylaxis. The drug acts on the thick segment of the ascending branch of the medullary collaterals, which can rapidly diuretic. It is commonly used in the treatment of congestive heart failure and hypertension. Furosemide promotes the excretion of sodium and potassium during diuresis, so it may cause side effects such as hyponatremia and hypokalemia. Clinically, spironolactone is often used in combination with furosemide, because spironolactone has a potassium-preserving effect, which can reduce furosemide-induced hyponatremia, electrolyte disorders and other adverse reactions, and the contraindications are not clear. It is worth noting that spironolactone and furosemide should be used under the guidance of a professional doctor, and should not be used without authorization, so as not to cause adverse consequences.