Every time in the middle of the night the heart fossa hidden pain, should improve the examination, may need to give acid suppression, antiplatelet, lipid regulation therapy. Every time in the middle of the night the heart fossa hidden pain, including gastric ulcer, duodenal ulcer, coronary heart disease angina attack. To improve gastroscopy, 13 carbon breath test, electrocardiogram, dynamic electrocardiogram, coronary angiography to confirm the diagnosis. Gastric ulcer and duodenal ulcer may manifest as acid reflux, heartburn, and pain in the heart socket. There is Helicobacter pylori infection, anti-Helicobacter pylori treatment, amoxicillin, clarithromycin, metronidazole, any two choose to take two weeks, colloidal bismuth pectin to take two weeks, acid suppression drug acepromazine omeprazole for 6~8 weeks. If you have acid reflux heartburn, reflux esophagitis, can be given acid suppression drugs at the same time add to improve gastric power drugs, such as domperidone. Coronary angina requires the administration of antiplatelets, such as aspirin, clopidogrel, etc.; and lipid-regulating drug therapy, atorvastatin, resuvastatin, etc.. Angina pectoris acute attack can be sublingual nitroglycerin and other relief of angina symptoms. In the middle of the night there is a hidden pain in the heart fossa, must promptly go to the hospital, improve the examination, according to the doctor’s prescription medication.