Negative urinary protein and elevated blood creatinine can be seen in physiologic and pathologic factors. Pathologic factors may be related to acute kidney injury or chronic kidney disease.
1. Physiological factors: after strenuous exercise or consuming a large amount of meat, muscle metabolism will be enhanced, and blood creatinine production will be increased, but urine protein is negative; after resting or vegetarian diet, blood creatinine will usually return to the normal level after review.
2. Pathological factors: common acute kidney injury is caused by renal stones, ureteral stones and other obstructive nephropathy leading to impaired glomerular filtration, blood creatinine increased; drug damage caused by interstitial nephritis leading to tubular damage, so that blood creatinine increased. At this time, urine protein can be negative.
In addition, diabetes, hypertension and other primary diseases caused by chronic kidney disease in the early stage, can also appear negative urine protein, blood creatinine is high.
Negative urine protein, high blood creatinine can also be seen in other reasons, it is recommended to consult a doctor in time, follow the doctor’s instructions for relevant examinations, with the help of the doctor to clarify the cause, and targeted treatment or therapy.