The indications for leukemia bone marrow transplantation are as follows: 1, acute leukemia: chemotherapy is preferred for high-risk acute leukemia, 1-2 courses of consolidation therapy after remission, and then allogeneic bone marrow transplantation is chosen; low to medium-risk patients can be consolidated for 1-2 courses of chemotherapy remission and then autologous transplantation is chosen or chemotherapy is discontinued for observation; 2, chronic myelogenous leukemia: tyrosine kinase inhibitors are preferred, such as imatinib treatment, and when drug resistance or gene mutation occurs, second or third generation tyrosine kinase inhibitors can be chosen. When drug resistance or even gene mutation occurs, second or third generation tyrosine kinase inhibitor drugs can be chosen, and allogeneic bone marrow transplantation is recommended after emergence of acute mutation; 3. Highly aggressive lymphoma leukemia: allogeneic transplantation after chemotherapy remission.