If mannitol crystallizes and enters the body’s circulation through blood vessels, it may cause sudden death. If the crystals enter the coronary arteries of the heart through the blood circulation, it is most likely to cause acute embolism of the coronary arteries, thus causing acute myocardial infarction, which may lead to chest pain, chest tightness, dizziness, fatigue and so on, and in the severe case, it may lead to acute malignant cardiac arrhythmia, or even acute cardiac arrest and death. In addition, if the crystallization enters into the brain through blood circulation, it will lead to acute cerebral infarction. Widespread cerebral infarction will affect the central nervous system, and the emergence of central respiratory failure will also lead to sudden death, and if it leads to acute pulmonary embolism, it may also lead to acute respiratory failure, which will lead to systemic hypoxia and sudden death.