Mean platelet volume is the average value of platelet volume. If it is simply slightly high, it is generally not clinically significant and indicates good bone marrow hematopoietic function and does not require special treatment. If the mean platelet volume is significantly high, or accompanied by significant coagulation abnormalities, it may be related to immune thrombocytopenic purpura, myelodysplastic syndrome, acute leukemia in remission, etc. 1. Immune thrombocytopenic purpura: Immune thrombocytopenic purpura patients are released from immature platelets in the bone marrow because of the dysfunction of platelets in the blood, which leads to a high mean platelet volume is high. Patients can be treated with medications such as glucocorticoids and immunosuppressants; 2. Myelodysplastic syndrome: Patients with myelodysplastic syndrome can cause anemia, resulting in high average platelet volume in the blood, and patients can be treated with medications such as immunosuppressants or immunomodulators; 3. Acute leukemia in remission: Acute leukemia in remission can also affect high average platelet volume values , which can be actively treated for acute leukemia to change the mean platelet volume. In addition to these, late pregnancy, megaloblastic anemia, thrombophilia, etc. can also affect the mean platelet volume. It is recommended to combine other test results, diagnose the disease, and treat the disease so as to improve the mean platelet volume.