Diarrhea after stopping quadruple drugs may be caused by adverse drug reactions or other diseases that cause diarrhea, as explained below. 1. Adverse drug reactions: quadruple drugs contain antibiotics, in the eradication of Helicobacter pylori at the same time, may also kill the beneficial intestinal bacteria, causing intestinal flora imbalance, resulting in diarrhea, diarrhea may appear in a few days after stopping the drug, but with the longer the drug stops, the adverse reaction will gradually subside, do not need to be overly concerned about it, if necessary, consult a doctor. 2. Other diseases causing diarrhea: with the discontinuation of the drug, the adverse effects of diarrhea will gradually disappear, if diarrhea occurs after discontinuation of the drug, it may be coincidental to the recent cold or unhygienic diet caused by the need to exclude these diseases, if the patient’s diarrhea is serious, please actively go to the hospital, so as to avoid delaying the condition. Patients taking quadruple drugs, need to strictly follow the doctor’s instructions, to avoid the abuse of antibiotics as well as drug resistance, after stopping the drug need to timely review, early recovery.