The normal value of total bile acids in newborns is 0-12 μmol/L. Of course, the range of normal values may vary slightly from hospital to hospital due to different reagents and measuring instruments, but the overall difference is not significant and should be judged according to the range of normal values given by the hospital. Total bile acids are mainly composed of bile acids, goose deoxycholic acid and deoxycholic acid, lithobiliary acid and ursodeoxycholic acid produced in metabolism. Total bile acids can be a good indicator of liver function. When hepatocellular damage or obstruction of intra- or extrahepatic bile ducts occurs, bile acids will be significantly abnormal and total bile acids will be significantly elevated, such as acute and chronic severe hepatitis, and common causes include viral hepatitis B, autoimmune hepatitis, EBV hepatitis, cytomegalovirus hepatitis. It may also be caused by biliary lesions, such as cholestatic cirrhosis, primary sclerosing cholangitis, congenital biliary atresia, and congenital bile duct dilatation. For clinical abnormalities of total bile acids, it is necessary to combine with relevant imaging and other auxiliary examinations to further determine the specific cause of the increased bile acids and provide timely treatment.