The hepatitis B virus may have existed on earth for a long time, but humans have only known about it for more than 50 years.1 In 1965, scientists discovered an antigenic substance in the blood of indigenous Australians and named this antigen the Australian antigen, or “Australian antigen” for short.2 In 1969, it was discovered that this antigenic substance was hepatophilic and aggressive to the human liver and was associated with inflammatory changes in the liver.3 In 1970, Dena et al. In 1970, Dena et al. observed the hepatitis B virus form under the electron microscope and named it Dena particles.4 In 1986, the hepatitis B virus was officially included in the family of hepatophilic DNA viruses, called hepatitis B virus, which is called hepatitis B virus in China.