Metronidazole gel to remove blackheads and acne is not effective. The main component of the drug is metronidazole, which is an anti-anaerobic, anti-protozoal and anti-mitotic antibiotic, and has good effects on some inflammatory acne lesions. However, blackheads are mainly due to the narrow keratinization of the opening of the upper part of the sebaceous gland of the hair follicle, and the sebum contents are secreted more and cannot be discharged smoothly, so they are blocked in the mouth of the hair follicle and are locally oxidized and blackened to form blackheads. The main treatment is to use drugs that regulate the keratinization of hair follicles and inhibit sebum secretion, and the more commonly used ones are vitamin A acid preparations, such as adapalene gel, which are more effective.