Blisters on the soles of the feet, if the blisters are small, you can temporarily do not have to poke, if the blisters are relatively large, you need to poke in time for treatment. 1. Temporarily do not use: blisters on the soles of the feet, generally repeated friction with the shoes, if the blisters are relatively small, the need to protect the affected area, the need to change a pair of loose shoes, try to avoid friction again, so as to avoid the blisters are getting bigger and bigger, generally can be absorbed by themselves, do not have to poke the treatment. 2. Timely puncture treatment: If the blisters on the soles of the feet are very large, and will be accompanied by obvious pain, in addition to avoiding friction again. You can use a sterilized needle or sterile syringe to puncture it in time, so that the liquid inside will flow out. In order to avoid rubbing the skin, contact with shoes and socks, and secondary infection. Therefore, each patient’s blisters on the soles of the feet of different sizes, the treatment is not the same, should be timely consultation and treatment as prescribed by the doctor.