Taking ibuprofen capsules or nimesulide granules for fever and headache is the most effective. Ibuprofen capsules and Nimesulide granules, both belong to non-steroidal anti-inflammatory and analgesic drugs, with antipyretic and analgesic effects, are commonly used antipyretic and analgesic drugs in clinical practice. Specific medication should be selected according to the body temperature, if the body temperature is above 38.5 ℃, you can take nimesulide granules to reduce fever, fever can also relieve the symptoms of headache. Fever and headache can be relieved quickly after taking antipyretics, but further examination is needed to find out what causes the fever and to give comprehensive treatment for the disease. If children have fever and headache, you can take ibuprofen suspension. While taking fever-reducing medication, you should pay attention to drink more water, to ensure adequate hydration, to prevent recurrent high fever or high fever persists.