Levofloxacin and Cephalosporin, these two medications, are two different classes of antibiotics. Levofloxacin is a quinolone antibiotic, cephalosporin is a cephalosporin antibiotic, the same are bactericidal antimicrobials, but the antibacterial spectrum is not the same. Cephalosporin antibiotics are mainly for gram-positive bacteria, staphylococci, mainly used in the upper respiratory tract, systemic infections. Levofloxacin is mainly for gram-negative bacteria, anaerobic bacteria are mainly used in the treatment of gastrointestinal tract and urinary tract infections.