There is no such thing as the safest gastric mucosal protector, and colloidal bismuth agents such as colloidal bismuth pectin and prostaglandins and their derivatives such as misoprostol can be taken orally for treatment. Colloidal bismuth is the more commonly used gastric mucosal protection drugs in clinic, including colloidal bismuth tartrate and colloidal bismuth pectin. The drug can form a sol in the acidic environment, and the sol can cover the gastric mucous membrane epithelium, constituting a layer of protective film, thus playing the role of gastric mucous membrane protection. Prostaglandins and their derivatives also have good gastric mucosal protection, commonly used drugs include misoprostol, the drug can significantly increase the synthesis of prostaglandins in the gastric mucosal cells, which in turn protects the gastric mucosa. The above drugs are prohibited for those who are allergic to them, and should be taken in accordance with medical advice, not blindly self-medication, in order to avoid adverse effects.