The treatment of cholestatic cirrhosis includes medication and surgery. 1. Drug therapy: commonly used drugs include ursodeoxycholic acid, glucocorticoid, immunosuppressant and other drugs. (1) Ursodeoxycholic acid: it is the first choice of therapeutic drugs for primary cholestatic cirrhosis, which is used to promote the secretion of bile, inhibit immune response, and protect the liver and bile ducts. (2) Glucocorticoid: it is suitable for patients with poor results of ursodeoxycholic acid treatment, and improves patients’ symptoms by improving their immune level. (3) Other drugs: for example, anticholinergic amines, used to relieve patients’ skin itching; vitamin K1, for patients with coagulation disorders. 2. Surgical treatment: surgical methods include hemostatic surgery, abdominal puncture, liver transplantation, and other surgeries. (1) Hemostatic surgery: applicable to patients with vascular rupture, often choose endoscopic hemostasis. (2) Laparotomy: for patients with symptoms of ascites, ascites is extracted through puncture. (3) Liver transplantation: a treatment suitable for patients in advanced stages, which can improve their symptoms and prolong their lives. (4) Other surgeries: patients with secondary biliary obstruction need to be treated for the cause of the disease, and the surgical methods include tumor resection and endoscopic bile duct stone removal. If cholestatic cirrhosis occurs, it is recommended to consult the doctor in time, and under the doctor’s guidance to formulate an appropriate treatment plan in conjunction with the condition, and the drugs should be used under the doctor’s guidance.