In general, women who are in their physiological period can receive the vaccine and it usually does not affect the effect of the vaccine or their menstrual cycle. However, the vaccine is a foreign substance to the human body and minor adverse reactions may occur in any population after vaccination, which is usually normal. Since women during their physiological period are usually weak and may suffer from discomfort such as back pain, weakness, abdominal pain, etc., it is recommended that women should try to get vaccinated during non-physiological periods if not necessary to avoid adverse reactions after vaccination and discomfort caused by the physiological period itself, which can be easily confused with adverse reactions after vaccination. If a woman has already received the vaccine during her physiological period, the possible widespread adverse reactions after vaccination mainly include local symptoms such as redness, swelling and pain at the injection site, and systemic symptoms such as malaise, mild rash and low fever, which can usually be relieved by themselves and are not related to a woman’s physiological period. In addition, there may be special symptoms related to the vaccine ingredients, own constitution and other factors. If a patient is allergic to vaccine components, symptoms such as high fever, vomiting, syncope, lethargy, hematuria, allergic rash, angioneurotic edema, anaphylaxis, toxic shock, etc. may occur. Then it is necessary to contact the vaccination site for record, and at the same time, depending on the type of vaccine and the degree of specific symptoms, call an ambulance or go to a hospital for consultation and treatment in time to avoid worsening of symptoms or causing life-threatening conditions.