The difference between pregnancy breast tenderness and premenstrual breast pain is: time of appearance, duration, touch sensation, hormone level, etc. 1. Appearance time: Pregnancy breast pain usually occurs after 10 days of menopause. Premenstrual breast pain usually occurs 1~2 weeks before the onset of menstruation. 2. Duration: Pregnancy breast pain usually lasts until the third trimester of pregnancy, or even throughout the entire pregnancy. Premenstrual breast pain usually returns to normal after the onset of menstruation or the end of menstruation. 3. Touch sensation: When you touch the breasts with your hands, they are usually soft and have no obvious hard lumps. Premenstrual breast pain, when you touch the breasts, you will find that the breasts are hard and there are hard lumps when you touch them. 4. Hormone levels are different: pregnancy breast pain is mostly due to the effects of estrogen and progesterone. Premenstrual breast pain is caused by the relatively high secretion of estrogen and the relatively low secretion of progesterone. Whether pregnant or premenstrual breast pain symptoms are more serious, it is recommended to consult a doctor in a timely manner, under the guidance of the normative treatment.