Bile reflux gastritis discomfort when standing upright is related to acid reflux in the stomach, the sequelae of gastric surgery, and abnormal biliary tract function. 1. Acid reflux in the stomach: acid reflux in the stomach can make bile reflux gastritis feel uncomfortable when standing upright, which makes the PH value of gastric mucosa in a lower state, the composition of bile and gastric acid does not match, the gastric acid is acidic and bile is alkaline, and bile refluxes into the stomach, leading to gastric mucosal damage, which destroys the protective layer. 2. Surgical sequelae: after duodenal surgery, the pylorus is removed, and the normal structure and function of the pylorus is damaged, losing the structure that prevents bile reflux, thus making it easy for bile reflux gastritis to occur and feel uncomfortable when it is upright. 3. Abnormal gastrointestinal function: biliary smooth muscle lesions, biliary obstruction, poor bile excretion, resulting in excessive bile in the biliary tract, making bile reflux gastritis upright with epigastric pain, fullness and discomfort, loss of appetite and other symptoms. When the symptoms of bile reflux gastritis are uncomfortable, you should go to the hospital in time to have a relevant examination, so as to clarify the cause of the disease and actively treat it.