Herpes simplex is an infectious skin disease. It typically manifests as clusters of small blisters around the eyes, mouth, and genitals, and is usually treated with medication. Herpes simplex is a skin disease mainly caused by the infection of the body with the herpes simplex virus. Herpes simplex virus infection may occur in many parts of the body, the typical symptom is a limited cluster of small blisters, preferably at the junction of the skin and mucous membranes, and the rash is often burning and itching. After rupture, vesicles and ulcers may appear. Some patients are left with temporary hyperpigmentation after healing. Herpes simplex relies mainly on medication in the clinic to reduce or eliminate symptoms, shorten the duration of lesions, prevent transmission, and reduce recurrence, and common medications include acyclovir, penciclovir, phosphinic acid sodium, and vasiclovir. Herpes simplex is self-limiting and usually has a good prognosis after drug treatment, but in some special cases, such as herpes keratitis and neonatal herpes, the lack of active treatment may leave eye disability or even death. Patients should follow the doctor’s instructions to actively cooperate with the doctor’s treatment, do not self-medication, in order to avoid delaying the condition or cause adverse reactions.