Enhancement scan shows significant enhancement, indicating that this lesion has a rich blood supply, for example, a hypodense shadow is found on the liver, and after enhancement scan the lesion shows nodular significant enhancement at the edge of the arterial phase, enlarged enhancement in the venous phase, and basically fills in the delayed phase with isointensity or high density. Based on the enhancement pattern of this lesion, it would be a significantly enhancing lesion and considered to be a hepatic hemangioma. In addition, focal nodular hyperplasia on the liver is also markedly enhancing in the arterial phase. Another type of marked enhancement is hepatocellular carcinoma, which has a fast-in and fast-out mode of enhancement and is mainly an arterial phase of blood supply. The lesions of hepatocellular carcinoma are significantly enhanced because the blood supply is more abundant. The lesion with significant enhancement needs to be considered according to the patient’s clinical history, the enhancement characteristics and location of the lesion, and the lesion with significant enhancement may be benign or malignant.