Symmetrical depression of both calves may be caused by lower limb vascular disease, heart disease, kidney disease and other reasons. 1. Lower limb vascular diseases: symmetrical depression of two calves is clinically known as phacoedema. The main reason for phacoedema in lower limb vascular diseases is due to obstruction of venous return in the lower limbs and stagnation of venous blood. Common diseases such as varicose veins of the lower limbs, deep vein thrombosis and so on. 2. Heart disease: the main reason for the emergence of concave edema in heart disease is due to the obstruction of body circulation. When the body circulation is obstructed, the venous blood return to the heart is blocked, and the blood is stagnated in the veins of the lower limbs, which leads to venous dilatation, and the loss of intravascular components to the tissue interstitial space, which leads to edema. Common diseases such as cardiac insufficiency, right heart failure and so on. 3. Renal disease: the main reason for the emergence of fingertip edema in renal disease is sodium retention due to the damage of glomerular basement membrane, increased permeability, increased plasma colloid osmolality and other reasons, resulting in the emergence of edema symptoms. Common diseases such as glomerulonephritis, nephrotic syndrome and so on. If the symptoms of symmetrical depression in both calves are not relieved, or accompanied by other symptoms, you should go to the hospital in time, and give targeted treatment after clarifying the cause.