People with gangrenous toes can be treated with medication as prescribed by the doctor, surgical treatment and hyperbaric oxygen therapy if necessary, and other measures such as daily care should be taken at the same time. 1. Drug treatment: patients with gangrenous toes need to take penicillin, erythromycin, metronidazole and other sensitive antibiotics according to the results of bacterial culture and medical advice. For pain symptoms, ibuprofen, acetaminophen, aspirin and other painkillers can be taken as prescribed by the doctor. 2. Surgical treatment: some patients can remove the necrotic tissue through debridement to prevent gangrene from spreading and promote tissue healing. For those who have broken skin due to gangrene, skin grafting or skin flap repair surgery is feasible. For serious condition, amputation is needed. 3. Hyperbaric Oxygen Therapy (HBOT): HBOT can help to inhibit the growth of germs and help the infected wounds to heal. 4. Others: Daily attention should be paid to strengthening foot care and keeping the wound clean and dry. Meanwhile, attention should be paid to a balanced diet to avoid abnormal blood sugar, which makes it difficult to recover from the disease. People with gangrenous toes are advised to seek further medical checkups so that they can choose the appropriate treatment according to their own conditions and under the guidance of doctors.