Non-Hodgkin’s B-cell lymphoma is a major pathological type of lymphoma, and another major pathological type is Hodgkin’s lymphoma. Non-Hodgkin’s B-cell lymphoma further includes low-grade malignant, moderately malignant, or highly aggressive B-cell lymphoma. The less malignant ones, such as chronic lymphocytic leukemia or small cell lymphoma, grades 1 and 2 of follicular lymphoma, and some pathological types of set cell lymphoma are inert lymphomas. Clinically, a watchful waiting strategy can be adopted, and treatment is given only when indicated. Diffuse large B-cell lymphoma is a moderately malignant non-Hodgkin’s B-cell lymphoma that requires treatment with immunochemotherapy. Burkitt’s lymphoma and high-grade lymphoma, which are very predisposed non-Hodgkin’s B-cell lymphomas. In conclusion, non-Hodgkin’s B-cell lymphoma is very common in clinical practice, and treatment should be based on the stage, nature of the pathology, type of pathology and the degree of malignancy, whether it is accompanied by clinical symptoms or not.