Buttock pain, thigh pain, calf pain, there is no clear best oral medication, drugs are only part of the treatment, should be based on the cause of the general treatment, drug therapy (non-steroidal pain relievers, nutrient-neurotropic drugs, muscle relaxants, etc.), physiotherapy and surgery, etc., the common causes of excessive exercise, lumbar spine disease, pyriformis muscle syndrome, and so on. 1. Excessive exercise: Due to excessive exercise, lactic acid accumulates in the body, which can cause physiological pain in the buttocks, thighs, calves and other parts of the muscles, which can be relieved after rest. 2. Lumbar spine disease: lumbar spine disease such as lumbar disc herniation can stimulate the nerve roots innervating the lower limbs and cause pain in the lower limbs. Oral non-steroidal painkillers, such as celecoxib, can be taken orally, but also oral methylcobalamin and other nutritive nerve drugs and epirubicin and other muscle relaxant drugs for treatment. Physical therapy such as lumbar traction and acupuncture can also be used under professional guidance. Surgery, such as minimally invasive nucleus pulposus removal, can be performed if conservative treatment is not effective. 3. Piriformis syndrome: contracture of the piriformis muscle caused by trauma, resulting in pressure on the adjacent sciatic nerve, causing pain and numbness in the lower limbs. Oral ibuprofen and other non-steroidal painkillers and methylcobalamin and other nutritive nerve medication, can also be combined with hot compresses, baked electricity and other physical therapy. Conservative treatment is ineffective can consider the pear muscle release surgery. There are other causes of pain in the buttocks and thighs, calves, such as trauma, tumors, etc., if the rest does not relieve, it is recommended to consult a doctor in a timely manner, improve the examination to clarify the cause of the disease, and comply with the doctor’s instructions to carry out targeted treatment, and do not blindly use their own medication, so as to avoid delaying the condition.