The pain in the hand from penicillin is caused by the stimulation of the endothelial cells of the veins by penicillin, which leads to sterile inflammation of the blood vessels and the surrounding tissues, stimulating the walls of the blood vessels and the surrounding nerves and producing pain. If pain occurs, it is recommended not to bury the indwelling needle to avoid aggravating the pain and the possibility of local phlebitis formation, as well as to reduce the speed of static dosing, and also to dilute the concentration of penicillin and increase the amount of liquid, and also to give hot towels to wet compresses when static dosing can alleviate the venous pain when dripping. The patient is recommended to make a fist after the static drip to avoid local stagnation of venous blood and the aggravation of phlebitis, which can even lead to occlusion of the venous cavity, and also to change to a different site for the next puncture static drip after a static drip, so as not to aggravate the pain and even the aggravation of phlebitis by multiple injuries in the same site static drip.