Variant asthma is clinically known as cough-variant asthma, and patients who are treated with salmeterol for control usually require long-term medication. Cough variant asthma is a kind of asthma with cough as the main manifestation. Salmeterol is a selective long-acting β2-adrenoceptor agonist drug, which has the effect of long-lasting dilation of bronchial tubes as well as reducing airway hyperresponsiveness. In patients with cough-variant asthma, it must be used daily to achieve good efficacy, so patients need to use the drug for a long time. The application of Salmeterol may cause throat dryness, irritation, headache, rash and other adverse reactions; hypersensitivity to the drug should be prohibited. Salmeterol can not replace the role of oral or inhaled corticosteroid drugs, when there is a deterioration of the condition, should consider starting corticosteroid treatment, cut acute attack patients are not suitable for the use of salmeterol. Cough variant asthma patients need to follow the doctor’s instructions to regulate the use of salmeterol, the specific drug program should be developed by the doctor.