Coughing up sputum with blood should be treated according to the cause, common causes include tuberculosis, bronchiectasis, lung abscess, etc., according to the cause of the drug treatment, surgical treatment, etc.. 1. Tuberculosis: coughing up sputum with blood caused by tuberculosis can be treated with anti-tuberculosis drugs, such as isoniazid, rifampicin, ethambutol, etc., and surgery can be taken if necessary. 2. Bronchodilatation: Bronchodilatation caused by coughing up sputum with blood can use some antiemetic drugs, such as Carbacillus, Yunnan Baiyao; combined with pathogenic infections require the use of antibiotics, such as amoxicillin, ciprofloxacin, etc., should be clear pathogens, and then choose the targeted drugs; and discretionary application of expectorant drugs, such as bromhexine, aminoglutethimide hydrochloride, etc.; if necessary, interventional therapy or surgical treatment. 3. Lung abscess: cough with blood caused by lung abscess should be treated with targeted antibiotics, such as staphylococcal and streptococcal infections can use penicillin, cephalosporin; medication is ineffective can be considered surgical treatment. The above mentioned drugs must be alert to drug-related side effects, under the guidance of professional physicians and pharmacists to apply, it is recommended to actively seek medical attention to clarify the cause, under the guidance of the doctor to carry out standardized treatment, to avoid private abuse of drugs.