Cervical biopsy results show p16-, ki67+, if the lesion range is within one-third, the disease is not serious, if the lesion range reaches or exceeds two-thirds, the condition is more serious, and need to do timely treatment. 1. serious: if the patient after doing a cervical biopsy results show p16-, ki67 + and lesions reach or exceed two thirds, may occur cervical pre-cancer or cervical carcinoma in situ, this disease is more serious, may lead to women with increased vaginal discharge, contact bleeding and other symptoms, to seek medical treatment in a timely manner. 2. not serious: if the lesion range is not more than one-third, it may be cervicitis or cervical low-grade intraepithelial neoplasia, the patient may be manifested in vaginal discharge odor, contact bleeding and other symptoms, can be under the guidance of the doctor for freezing, laser, microwave and other treatments, usually the prognosis is better. Cervical biopsy results show p16-, ki67+ whether serious need to patients to the hospital for further examination, but also need to be combined with other test results to make an accurate judgment, and then do further treatment.