Vulvovaginal itching and rupture may be caused by vulvovaginal pseudomycosis, bacterial vaginosis, atrophic vaginitis, vulvar leukoplakia, vulvar cancer, etc. Anti-fungal, bacterial and estrogenic ointments should be used according to the cause of the disease. 1. Vulvovaginal pseudomycosis: it can be manifested as vulvar itching, edema, severe cases can be seen skin ulceration, epidermal detachment and so on. Clinical treatment can be used for clotrimazole preparation, miconazole preparation, etc. applied to the deep part of the vagina. Its adverse reactions are local irritation, itching or burning sensation. 2. Bacterial vaginosis: symptoms such as vulvar itching or burning sensation may occur. Clindamycin ointment can be applied to the vagina for treatment, and allergic reactions such as skin dryness, local irritation and rash may occur. 3. Atrophic vaginitis: it is caused by the decrease of estrogen level and resistance. It can be treated by supplementing estrogen, applying estriol ointment to the vagina, as well as applying antibiotics such as norfloxacin preparation to inhibit the growth of bacteria. 4. Vulvar leukoplakia: caused by local nerve and blood vessel nutritional disorders of the vulva, hormone medicines can be used to apply locally, such as fluoride acetate ointment. 5. Vulvar cancer: it is a malignant tumor of vulva, usually the effect of drug treatment is not good, and it needs surgical treatment. In addition, due to the different contraindications and side effects of different medicines, they should be used in strict accordance with the doctor’s prescription, and should not be used privately to avoid adverse consequences.