1. Pregnancy-related heart disease: this is a serious obstetrical complication, and is still the main cause of maternal mortality, with a morbidity rate of 0.5 to 1.5 per cent. As a result of pregnancy, the uterus increases in size, blood volume increases, increasing the burden on the heart, the uterus and the whole body contraction of skeletal muscles during labor and delivery makes a large amount of blood rushing to the heart, and the increase in the amount of circulating blood after delivery is easy to make the heart of the heart with lesions occur heart failure. At the same time, due to long-term chronic hypoxia, resulting in intrauterine fetal growth failure and fetal distress. Whether a patient with heart disease can safely survive pregnancy and childbirth depends on the function of the heart, so this disease must be highly valued. Choice of delivery method: Pregnant mothers with this type of disease should choose a suitable delivery method in advance. For those with cardiac function class I-II, small fetus, normal fetal position and good cervical conditions, vaginal delivery under close supervision may be considered. For those with small fetus, poor birth canal conditions and cardiac function grade III-IV, caesarean section should be chosen. 2.Severe hepatitis in pregnancy: Symptoms of severe hepatitis in pregnancy include loss of appetite, anorexia, frequent vomiting, abdominal distension, followed by fatigue, yellowish skin, dark yellow urine, gastrointestinal hemorrhage, ascites, indifference, drowsiness, and so on. On the basis of liver failure, postpartum hemorrhage due to coagulation dysfunction, gastrointestinal hemorrhage, and infections are the causative factors, which ultimately lead to hepatic encephalopathy and hepatorenal syndrome, which is one of the major causes of maternal mortality. Viral hepatitis in pregnancy, the fetus can be infected through vertical transmission, by hepatitis B mother-to-child transmission rate is higher. Viral hepatitis is closely related to the development of Down syndrome. The incidence of fetal malformation is about two times higher in early pregnancy with viral hepatitis. Miscarriage, preterm labor, stillbirth, stillbirth and neonatal mortality are all significantly higher. Choice of mode of delivery: most scholars prefer cesarean section, cesarean section patients mortality rate than vaginal delivery decreased significantly, if at the same time the hysterectomy can also prevent postpartum hemorrhage and puerperal infection. 3, hyperthyroidism: hyperthyroidism is the body’s thyroid hormone is too high, causing the body’s nervous, circulatory, digestive and other systems of increased excitability and hypermetabolic endocrine diseases. The common cause is toxic diffuse goiter. Maternal manifestations in normal pregnancy are, palpitations, heart rate more than 100 beats/minute at rest, very good appetite, eating a lot of food, pregnant women’s weight can not be increased according to the gestational week, diarrhea, pulse pressure > 50mmHg, fear of heat and sweating, skin flushing, increased skin temperature. Hypermetabolism in patients with hyperthyroidism cannot provide sufficient nutrition for the fetus, fetal growth restriction, high birth rate of low birth weight babies. Silent anti-hyperthyroidism drugs can enter the fetus through the placenta, causing fetal and neonatal hypothyroidism. Some drugs have a risk of teratogenicity to the fetus. Choice of mode of delivery: Admission to the hospital at 37-38 weeks of gestation for monitoring and to decide on the mode of delivery. Except for obstetric factors, delivery should be vaginal as far as possible. After labor, give mental comfort, reduce pain; inhale oxygen, pay attention to replenish energy, shorten the second stage of labor. For severe cases, surgical assisted delivery is needed. Whether vaginal delivery or cesarean section, infection should be prevented, complications should be prevented, and attention should be paid to postpartum hemorrhage and thyroid crisis.