If the lung nodules do not change during chemotherapy for breast cancer, if the nodules are benign and small, they generally have little effect and can be treated without special treatment; larger benign nodules can be surgically removed. However, if the malignant nodule remains unchanged, it can be combined with radiotherapy and targeted therapy. 1. Benign nodule: if it is a relatively small benign nodule, it can be observed temporarily without special treatment; for relatively large benign nodule, it can be surgically removed in time without affecting the chemotherapy of breast cancer. 2. Malignant nodule: if it belongs to lung metastasis and the effect of chemotherapy for breast cancer is not good, radiotherapy can be considered to inhibit the cancer cells, and during the period, it can also be combined with targeted therapy to control the cancer cells, for example, trastuzumab and lapatinib. Breast cancer patients need regular review during the chemotherapy period to understand the effect obtained after chemotherapy and adjust the treatment plan appropriately according to individual situation.