Whether renal insufficiency can do painless gastroscopy is related to the patient’s condition, if the patient’s condition is mild and can bear anesthesia, it can be done, on the contrary, if the patient’s condition is serious, it is generally not recommended to do painless gastroscopy. Painless gastroscopy is based on ordinary gastroscopy, injecting a certain dose of anesthesia into the patient, so that the patient is in a state of sedation and sleep, which can reduce the pain of the patient to do gastroscopy. However, due to the need for anesthesia during the examination, not all people are suitable for painless gastroscopy. Patients with renal insufficiency who are in mild condition, with better glomerular filtration rate, and whose physical condition can withstand anesthesia can usually have painless gastroscopy after comprehensive assessment by the doctor; however, if the patient’s condition is more serious, with severe edema and other symptoms, and when the patient’s physical condition is poor, it is usually not recommended to have painless gastroscopy. For patients with renal insufficiency, painless gastroscopy is usually not recommended if they can tolerate ordinary gastroscopy, so as not to aggravate the metabolic burden of the kidneys due to the injection of anesthetic. Patients with renal insufficiency are advised to consult their doctors in advance before undergoing painless gastroscopy, and make a reasonable choice under their doctors’ guidance.