Blisters on the palms of the hands may be caused by friction and pressure, or eczema, ringworm and other diseases, determine the cause of the disease and then treat it with medication. 1. Friction and pressure cause skin damage, resulting in blisters, if the blisters are small, they can slowly subside after the absorption of tissue fluid; larger blisters require a sterile needle to suck up the blister fluid to help recovery. 2. Eczema can appear papules, pustular papules, may be accompanied by localized intense itching, but also may have the symptom of peeling. It can be treated with oral chlorpheniramine maleate tablets and fexofenadine hydrochloride tablets under the guidance of a doctor, as well as topical glycerine lotion, boric acid solution, and glucocorticosteroids such as hydrocortisone butyrate ointment. 3. Tinea versicolor can also be manifested as blisters, distributed in groups or scattered, with thick walls and clarified blister fluid. Treatment can be topical antifungal drugs such as miconazole nitrate, terbinafine cream, etc., or oral terbinafine, itraconazole and other treatment. Palm long blisters may also be caused by other diseases, it is recommended to seek timely medical attention.