The proper way to use metformin extended-release tablets is to swallow them whole and take them with a meal. Start with a small dose, taken once a day, usually with dinner, and gradually increase the dose. The exact dosage varies somewhat depending on the individual, so please follow your doctor’s instructions. Metformin belongs to the class of biguanide glucose-lowering drugs, which can inhibit hepatic glucose output, increase the utilization of glucose in peripheral tissues, and increase the sensitivity of insulin. It is currently the first-line drug for the treatment of type 2 diabetes. Metformin extended-release tablets are swallowed whole and taken with a meal, or if taken only once a day it is recommended to take it with dinner. Start with a small dose and gradually increase the dose. The exact dosage varies somewhat depending on the individual, so please follow your doctor’s instructions. Common adverse reactions to metformin include gastrointestinal reactions, skin irritation and lactic acidosis. It is contraindicated in patients with hypersensitivity to the drug, severe renal failure and acute metabolic acidosis. Patients who need to take metformin extended-release tablets should be under the guidance of a doctor.