The risk of hypoglycemia is high with the combined use of insulin and nateglinide, and it is generally not recommended to use them together, and they should be used reasonably under the guidance of a doctor. 1. Insulin: It is mainly applied to patients with type 2 diabetes mellitus who are combined with various acute and chronic complications, those with markedly reduced β-cell function, and those who are ineffective in diet, exercise, and oral hypoglycemic drugs. Common adverse reactions include hypoglycemia, urticaria, etc. Hypoglycemic episodes and hypersensitivity to insulin are prohibited. 2. Nateglinide: belongs to non-sulfonylurea drugs, mainly through stimulating the pancreatic β-cells to secrete insulin, so as to reduce blood glucose, mainly used for controlling postprandial blood glucose. Common adverse reactions are hypoglycemia and weight gain. It is forbidden to use for ketoacidosis, pregnant or lactating women or those who are allergic to this product, and should not be used by those with low pancreatic islet function. Insulin and Nateglinide are both prescription drugs, need to be used under the guidance of a doctor, can not be blindly used together, it is recommended to consult a professional doctor before use.