Tongue hypertrophy may be caused by angioedema, tongue tissue infection, restrictive myositis, tongue trauma, Beckwith-Wiedemann syndrome, tongue amyloidosis, multiple myeloma, etc., and the cause of the disease should be identified by timely consultation. 1. Angioedema: allergens lead to dilation and increased permeability of small blood vessels within the tongue tissue, causing limited edema of the tongue tissue, leading to hypertrophy of the tongue. 2. Tongue tissue infection, limited myositis: under the stimulation of inflammatory factors, small blood vessels in the tongue dilate and permeability increases, causing tongue tissue edema. 3. Tongue trauma: tongue tissue injury causes blood vessel rupture and blood accumulation within the tongue, causing limited swelling of tongue tissue, leading to tongue hypertrophy. 4. Beckwith-Wiedemann syndrome: diffuse hyperplasia of tongue tissue and hypertrophy of muscle fibers, leading to tongue hypertrophy. 5. Tongue amyloidosis, multiple myeloma: abnormal deposition of amyloid protein (including M protein light chain and polysaccharide complex) in the tongue tissue, leading to tongue hypertrophy. However, other factors can not be ruled out, it is recommended to consult a doctor in time to clarify the cause of the disease, and then give targeted treatment.