The proximal tubule is an elongated epithelial tubule that is connected to the wall layer of the renal capsule and has a reabsorptive and excretory role. The renal tubules are divided into three parts according to different morphological structures, distribution locations and functions; the proximal tubule, the fine segment and the distal tubule. The proximal tubule can be divided into straight and curved sections. The curved part, also known as the proximal tubule, is located in the cortical labyrinth and is highly coiled near the renal tubule. What is the pathogenesis of proximal tubule involvement? Here is a brief introduction. The pathogenesis of proximal tubular involvement can be caused by the presence of one of the three components: a dramatic decrease in renal blood flow due to certain causes, severe renal underperfusion or renal disorders affecting glomerular filtration function and lower urinary tract obstruction. For example, in the early stages of hypovolemia, the kidney is only underperfused, but if it is not diagnosed and treated in time, it can lead to parenchymal damage, and even if the blood volume is replenished, the urine volume cannot be restored immediately. In the early stage of lower urinary tract obstruction, the filtration function of the kidney is still normal, but if the obstruction cannot be lifted at the right time, a large amount of fluid in the renal pelvis will compress the renal parenchyma and cause cortical atrophy, which will seriously affect glomerular filtration, and at this time, even if the urinary tract obstruction is lifted, the urine volume cannot be increased immediately. In renal parenchymal disorders, if left untreated, edema gradually worsens, affecting the function of the gastrointestinal tract and causing a decrease in blood volume, which accelerates the damage to renal function and further reduces urine volume. Proximal tubular involvement seriously affects our daily life, it is recommended that patients actively go to professional and regular hospitals for systematic diagnosis and treatment to avoid delaying the disease.